Antigenic Variation in Plasmodium falciparum Infected Erythrocytes (3160)
Selected reading:
- Miller et al (2002) The pathogenic basis of malaria. Nature 415:673-9
- Deitsch & Hviid (2004) Variant surface antigens, virulence genes and the pathogenesis of malaria. Trends in Parasitol 20:562-66
- Kraemer & Smith (2006) A family affair: var genes, PfEMP1 binding, and malaria disease. Curr. Opin. Microbiol. 4:374-80
- Scherf et al (2008) Antigenic variation in Plasmodium falciparum. Ann. Rev. Microbiol. 62:445-70
P. falciparum life cycle: Animation
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Structure and Organisation of Chromosomes (3158)
Tue 3rd Mar: 11am.
Selected reading:
- Book chapter: The flow of genetic information PDF
Chromatin packaging animation
Additional animations
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Trypanosome Molecular Biology: Antigenic Variation in Trypanosoma brucei (3160)
Selected reading:
- Pays (2005) Regulation of antigen gene expression in Trypanosoma brucei. Trends Parasitol 21:517-20.
- Baral TN et al., (2006) Experimental therapy of African trypanosomiasis with a nanobody-conjugated human trypanolytic factor. Nature Med. 12:580-4.
- Taylor JE and Rudenko G. (2006) Switching trypanosome coats: what’s in the wardrobe? Trends Genet. 22:614-20.
- TriTryp sequencing papers: 2005 in Science
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Antimicrobial Chemotherapy - syndicate (3169)
Wed 22nd April: 4pm.
Selected reading:
- Bray et al (2003) Pentamidine uptake and resistance in pathogenic protozoa. Trends Parasitol 5:232-9
- Gelb et al (2003) Protein farnesyl and N-myristoyl transferases. Mol Biochem Parasitol 126:155-63
- Smith et al (2004) GPI biosynthesis as a drug target against African sleeping sickness. EMBO J 23:4701-8
- Cowman & Crabb (2003) Functional genomics: identifying drug targets for parasitic diseases. Trends Parasitol 11:538-43
- Gelb & Hol (2002) Drugs to combat tropical protozoan parasites. Science 297:343-4
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| Gene Expression in Prokaryotes and Eukaryotes (C3333) |
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| African Trypanosomaiasis: Life Cycle and Pathology (3122) |
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